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Figure 1 CXCL16, <t>CXCR6,</t> sCXCL16, and circulating Tregs in GIST specimens. Notes: (A) Western blot analysis for CXCL16 and CXCR6 expression in specimens. β-actin was used as an internal loading control. (B) Representative results of GIST cancer tissues and corresponding noncancerous tissue by immunohistochemical staining. The nuclei were counterstained with hematoxylin. (C) sCXCL16 level in serum of the GIST patients was detected by using ELISA. (D) Circulating Tregs were determined by using fluorescence-activated cell sorting. (E) Positive correlation between sCXCL16 and Tregs in serum of the GIST patients. Abbreviations: GIST, gastrointestinal stromal tumors; ELISA, enzyme-linked immunosorbent assay; N, normal; C, cancer; sCXCL16, serum CXCL16.
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CXCL16, <t>CXCR6,</t> sCXCL16, and circulating Tregs in GIST specimens. Notes: ( A ) Western blot analysis for CXCL16 and CXCR6 expression in specimens. β-actin was used as an internal loading control. ( B ) Representative results of GIST cancer tissues and corresponding noncancerous tissue by immunohistochemical staining. The nuclei were counterstained with hematoxylin. ( C ) sCXCL16 level in serum of the GIST patients was detected by using ELISA. ( D ) Circulating Tregs were determined by using fluorescence-activated cell sorting. ( E ) Positive correlation between sCXCL16 and Tregs in serum of the GIST patients. Abbreviations: GIST, gastrointestinal stromal tumors; ELISA, enzyme-linked immunosorbent assay; N, normal; C, cancer; sCXCL16, serum CXCL16.
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Figure 1 CXCL16, CXCR6, sCXCL16, and circulating Tregs in GIST specimens. Notes: (A) Western blot analysis for CXCL16 and CXCR6 expression in specimens. β-actin was used as an internal loading control. (B) Representative results of GIST cancer tissues and corresponding noncancerous tissue by immunohistochemical staining. The nuclei were counterstained with hematoxylin. (C) sCXCL16 level in serum of the GIST patients was detected by using ELISA. (D) Circulating Tregs were determined by using fluorescence-activated cell sorting. (E) Positive correlation between sCXCL16 and Tregs in serum of the GIST patients. Abbreviations: GIST, gastrointestinal stromal tumors; ELISA, enzyme-linked immunosorbent assay; N, normal; C, cancer; sCXCL16, serum CXCL16.

Journal: OncoTargets and Therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/ott.s105245

Figure Lengend Snippet: Figure 1 CXCL16, CXCR6, sCXCL16, and circulating Tregs in GIST specimens. Notes: (A) Western blot analysis for CXCL16 and CXCR6 expression in specimens. β-actin was used as an internal loading control. (B) Representative results of GIST cancer tissues and corresponding noncancerous tissue by immunohistochemical staining. The nuclei were counterstained with hematoxylin. (C) sCXCL16 level in serum of the GIST patients was detected by using ELISA. (D) Circulating Tregs were determined by using fluorescence-activated cell sorting. (E) Positive correlation between sCXCL16 and Tregs in serum of the GIST patients. Abbreviations: GIST, gastrointestinal stromal tumors; ELISA, enzyme-linked immunosorbent assay; N, normal; C, cancer; sCXCL16, serum CXCL16.

Article Snippet: The half maximal inhibitory concentration (IC 50 ) values of recombinant CXCL16 for Tregs, GIST-T1 cells, and GIST882 cells were determined and used in the following studies. gene transfection CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Western Blot, Expressing, Control, Immunohistochemical staining, Staining, Enzyme-linked Immunosorbent Assay, Fluorescence, FACS

Figure 2 Kaplan–Meier curves of the cumulative survival rate of patients with GIST. Notes: Based on patients’ CXCL16 (A), CXCR6 (B), sCXCL16 (C) expression or circulating Tregs number (D). Abbreviations: GIST, gastrointestinal stromal tumors; sCXCL16, serum CXCL16.

Journal: OncoTargets and Therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/ott.s105245

Figure Lengend Snippet: Figure 2 Kaplan–Meier curves of the cumulative survival rate of patients with GIST. Notes: Based on patients’ CXCL16 (A), CXCR6 (B), sCXCL16 (C) expression or circulating Tregs number (D). Abbreviations: GIST, gastrointestinal stromal tumors; sCXCL16, serum CXCL16.

Article Snippet: The half maximal inhibitory concentration (IC 50 ) values of recombinant CXCL16 for Tregs, GIST-T1 cells, and GIST882 cells were determined and used in the following studies. gene transfection CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Expressing

Figure 3 Recombinant CXCL16 (IC50 value) displays inhibitory effects on Tregs and GIST cells in vitro. Notes: (A) The proliferation ratio was determined by MTT assays. (B) Cells were stained with propidium iodide and fluorescence-activated cell sorting analysis was performed. (C) Transwell assays were performed to detect migration and invasion of cells. Cells that migrated to the bottom of the membrane were stained and counted. Treg: untreated Tregs; Treg-C: Tregs treated with recombinant CXCL16; Treg-C+S: Tregs treated with recombinant CXCL16 and CXCR6 siRNA; GIST-T1: untreated GIST-T1 cells; GIST- T1-C: GIST-T1 cells treated with recombinant CXCL16; GIST-T1-C+S: GIST-T1 cells treated with recombinant CXCL16 and CXCR6 siRNA; GIST882: untreated GIST882 cells; GIST882-C: GIST882 cells treated with recombinant CXCL16; GIST882-C+S: GIST882 cells treated with recombinant CXCL16 and CXCR6 siRNA. Abbreviations: GIST, gastrointestinal stromal tumors; PI, propidium iodide; IC50, half maximal inhibitory concentration; rhCXCL16, recombinant human CXCL16.

Journal: OncoTargets and Therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/ott.s105245

Figure Lengend Snippet: Figure 3 Recombinant CXCL16 (IC50 value) displays inhibitory effects on Tregs and GIST cells in vitro. Notes: (A) The proliferation ratio was determined by MTT assays. (B) Cells were stained with propidium iodide and fluorescence-activated cell sorting analysis was performed. (C) Transwell assays were performed to detect migration and invasion of cells. Cells that migrated to the bottom of the membrane were stained and counted. Treg: untreated Tregs; Treg-C: Tregs treated with recombinant CXCL16; Treg-C+S: Tregs treated with recombinant CXCL16 and CXCR6 siRNA; GIST-T1: untreated GIST-T1 cells; GIST- T1-C: GIST-T1 cells treated with recombinant CXCL16; GIST-T1-C+S: GIST-T1 cells treated with recombinant CXCL16 and CXCR6 siRNA; GIST882: untreated GIST882 cells; GIST882-C: GIST882 cells treated with recombinant CXCL16; GIST882-C+S: GIST882 cells treated with recombinant CXCL16 and CXCR6 siRNA. Abbreviations: GIST, gastrointestinal stromal tumors; PI, propidium iodide; IC50, half maximal inhibitory concentration; rhCXCL16, recombinant human CXCL16.

Article Snippet: The half maximal inhibitory concentration (IC 50 ) values of recombinant CXCL16 for Tregs, GIST-T1 cells, and GIST882 cells were determined and used in the following studies. gene transfection CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Recombinant, In Vitro, Staining, Fluorescence, FACS, Migration, Membrane, Concentration Assay

Figure 4 Western blot analysis of the ERK/MEK signaling pathway. Notes: Recombinant CXCL16 could induce increased E-cadherin, and decreased p-ERK, p-MEK, MMP2/9, and N-cadherin. However, ERK and MEK showed no changes. β-actin was used as an internal loading control. Treg: untreated Tregs; Treg-C: Tregs treated with recombinant CXCL16; Treg-C+S: Tregs treated with recombinant CXCL16 and CXCR6 siRNA; GIST-T1: untreated GIST-T1 cells; GIST-T1-C: GIST-T1 cells treated with recombinant CXCL16; GIST-T1-C+S: GIST-T1 cells treated with recombinant CXCL16 and CXCR6 siRNA; GIST882: untreated GIST882 cells; GIST882-C: GIST882 cells treated with recombinant CXCL16; GIST882-C+S: GIST882 cells treated with recombinant CXCL16 and CXCR6 siRNA. Abbreviation: GIST, gastrointestinal stromal tumors.

Journal: OncoTargets and Therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/ott.s105245

Figure Lengend Snippet: Figure 4 Western blot analysis of the ERK/MEK signaling pathway. Notes: Recombinant CXCL16 could induce increased E-cadherin, and decreased p-ERK, p-MEK, MMP2/9, and N-cadherin. However, ERK and MEK showed no changes. β-actin was used as an internal loading control. Treg: untreated Tregs; Treg-C: Tregs treated with recombinant CXCL16; Treg-C+S: Tregs treated with recombinant CXCL16 and CXCR6 siRNA; GIST-T1: untreated GIST-T1 cells; GIST-T1-C: GIST-T1 cells treated with recombinant CXCL16; GIST-T1-C+S: GIST-T1 cells treated with recombinant CXCL16 and CXCR6 siRNA; GIST882: untreated GIST882 cells; GIST882-C: GIST882 cells treated with recombinant CXCL16; GIST882-C+S: GIST882 cells treated with recombinant CXCL16 and CXCR6 siRNA. Abbreviation: GIST, gastrointestinal stromal tumors.

Article Snippet: The half maximal inhibitory concentration (IC 50 ) values of recombinant CXCL16 for Tregs, GIST-T1 cells, and GIST882 cells were determined and used in the following studies. gene transfection CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Western Blot, Recombinant, Control

CXCL16, CXCR6, sCXCL16, and circulating Tregs in GIST specimens. Notes: ( A ) Western blot analysis for CXCL16 and CXCR6 expression in specimens. β-actin was used as an internal loading control. ( B ) Representative results of GIST cancer tissues and corresponding noncancerous tissue by immunohistochemical staining. The nuclei were counterstained with hematoxylin. ( C ) sCXCL16 level in serum of the GIST patients was detected by using ELISA. ( D ) Circulating Tregs were determined by using fluorescence-activated cell sorting. ( E ) Positive correlation between sCXCL16 and Tregs in serum of the GIST patients. Abbreviations: GIST, gastrointestinal stromal tumors; ELISA, enzyme-linked immunosorbent assay; N, normal; C, cancer; sCXCL16, serum CXCL16.

Journal: OncoTargets and therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/OTT.S105245

Figure Lengend Snippet: CXCL16, CXCR6, sCXCL16, and circulating Tregs in GIST specimens. Notes: ( A ) Western blot analysis for CXCL16 and CXCR6 expression in specimens. β-actin was used as an internal loading control. ( B ) Representative results of GIST cancer tissues and corresponding noncancerous tissue by immunohistochemical staining. The nuclei were counterstained with hematoxylin. ( C ) sCXCL16 level in serum of the GIST patients was detected by using ELISA. ( D ) Circulating Tregs were determined by using fluorescence-activated cell sorting. ( E ) Positive correlation between sCXCL16 and Tregs in serum of the GIST patients. Abbreviations: GIST, gastrointestinal stromal tumors; ELISA, enzyme-linked immunosorbent assay; N, normal; C, cancer; sCXCL16, serum CXCL16.

Article Snippet: CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Western Blot, Expressing, Control, Immunohistochemical staining, Staining, Enzyme-linked Immunosorbent Assay, Fluorescence, FACS

Relationship between CXCL16 and CXCR6 expression in situ and clinicopathological parameters of patients with GIST

Journal: OncoTargets and therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/OTT.S105245

Figure Lengend Snippet: Relationship between CXCL16 and CXCR6 expression in situ and clinicopathological parameters of patients with GIST

Article Snippet: CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Expressing, In Situ

Kaplan–Meier curves of the cumulative survival rate of patients with GIST. Notes: Based on patients’ CXCL16 ( A ), CXCR6 ( B ), sCXCL16 ( C ) expression or circulating Tregs number ( D ). Abbreviations: GIST, gastrointestinal stromal tumors; sCXCL16, serum CXCL16.

Journal: OncoTargets and therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/OTT.S105245

Figure Lengend Snippet: Kaplan–Meier curves of the cumulative survival rate of patients with GIST. Notes: Based on patients’ CXCL16 ( A ), CXCR6 ( B ), sCXCL16 ( C ) expression or circulating Tregs number ( D ). Abbreviations: GIST, gastrointestinal stromal tumors; sCXCL16, serum CXCL16.

Article Snippet: CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Expressing

Recombinant CXCL16 (IC 50 value) displays inhibitory effects on Tregs and GIST cells in vitro. Notes: ( A ) The proliferation ratio was determined by MTT assays. ( B ) Cells were stained with propidium iodide and fluorescence-activated cell sorting analysis was performed. ( C ) Transwell assays were performed to detect migration and invasion of cells. Cells that migrated to the bottom of the membrane were stained and counted. Treg: untreated Tregs; Treg-C: Tregs treated with recombinant CXCL16; Treg-C+S: Tregs treated with recombinant CXCL16 and CXCR6 siRNA; GIST-T1: untreated GIST-T1 cells; GIST-T1-C: GIST-T1 cells treated with recombinant CXCL16; GIST-T1-C+S: GIST-T1 cells treated with recombinant CXCL16 and CXCR6 siRNA; GIST882: untreated GIST882 cells; GIST882-C: GIST882 cells treated with recombinant CXCL16; GIST882-C+S: GIST882 cells treated with recombinant CXCL16 and CXCR6 siRNA. Abbreviations: GIST, gastrointestinal stromal tumors; PI, propidium iodide; IC 50 , half maximal inhibitory concentration; rhCXCL16, recombinant human CXCL16.

Journal: OncoTargets and therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/OTT.S105245

Figure Lengend Snippet: Recombinant CXCL16 (IC 50 value) displays inhibitory effects on Tregs and GIST cells in vitro. Notes: ( A ) The proliferation ratio was determined by MTT assays. ( B ) Cells were stained with propidium iodide and fluorescence-activated cell sorting analysis was performed. ( C ) Transwell assays were performed to detect migration and invasion of cells. Cells that migrated to the bottom of the membrane were stained and counted. Treg: untreated Tregs; Treg-C: Tregs treated with recombinant CXCL16; Treg-C+S: Tregs treated with recombinant CXCL16 and CXCR6 siRNA; GIST-T1: untreated GIST-T1 cells; GIST-T1-C: GIST-T1 cells treated with recombinant CXCL16; GIST-T1-C+S: GIST-T1 cells treated with recombinant CXCL16 and CXCR6 siRNA; GIST882: untreated GIST882 cells; GIST882-C: GIST882 cells treated with recombinant CXCL16; GIST882-C+S: GIST882 cells treated with recombinant CXCL16 and CXCR6 siRNA. Abbreviations: GIST, gastrointestinal stromal tumors; PI, propidium iodide; IC 50 , half maximal inhibitory concentration; rhCXCL16, recombinant human CXCL16.

Article Snippet: CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Recombinant, In Vitro, Staining, Fluorescence, FACS, Migration, Membrane, Concentration Assay

Western blot analysis of the ERK/MEK signaling pathway. Notes: Recombinant CXCL16 could induce increased E-cadherin, and decreased p-ERK, p-MEK, MMP2/9, and N-cadherin. However, ERK and MEK showed no changes. β-actin was used as an internal loading control. Treg: untreated Tregs; Treg-C: Tregs treated with recombinant CXCL16; Treg-C+S: Tregs treated with recombinant CXCL16 and CXCR6 siRNA; GIST-T1: untreated GIST-T1 cells; GIST-T1-C: GIST-T1 cells treated with recombinant CXCL16; GIST-T1-C+S: GIST-T1 cells treated with recombinant CXCL16 and CXCR6 siRNA; GIST882: untreated GIST882 cells; GIST882-C: GIST882 cells treated with recombinant CXCL16; GIST882-C+S: GIST882 cells treated with recombinant CXCL16 and CXCR6 siRNA. Abbreviation: GIST, gastrointestinal stromal tumors.

Journal: OncoTargets and therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/OTT.S105245

Figure Lengend Snippet: Western blot analysis of the ERK/MEK signaling pathway. Notes: Recombinant CXCL16 could induce increased E-cadherin, and decreased p-ERK, p-MEK, MMP2/9, and N-cadherin. However, ERK and MEK showed no changes. β-actin was used as an internal loading control. Treg: untreated Tregs; Treg-C: Tregs treated with recombinant CXCL16; Treg-C+S: Tregs treated with recombinant CXCL16 and CXCR6 siRNA; GIST-T1: untreated GIST-T1 cells; GIST-T1-C: GIST-T1 cells treated with recombinant CXCL16; GIST-T1-C+S: GIST-T1 cells treated with recombinant CXCL16 and CXCR6 siRNA; GIST882: untreated GIST882 cells; GIST882-C: GIST882 cells treated with recombinant CXCL16; GIST882-C+S: GIST882 cells treated with recombinant CXCL16 and CXCR6 siRNA. Abbreviation: GIST, gastrointestinal stromal tumors.

Article Snippet: CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: Western Blot, Recombinant, Control

Multivariate analysis of clinical variables for patients with GIST

Journal: OncoTargets and therapy

Article Title: The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

doi: 10.2147/OTT.S105245

Figure Lengend Snippet: Multivariate analysis of clinical variables for patients with GIST

Article Snippet: CXCR6 siRNA (sc-39895) was obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).

Techniques: